Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition it contributes to the integrity of the blood vessels.
Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis.
Hesperidin is also a sedative, possibly acting through opioid or adenosine receptors. Some in vitro results applied only to the aglucone form. Hesperidin also showed the ability to penetrate the blood brain barrier in an in vitro model.
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